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Test ID: HAIGG Hepatitis A IgG Antibody, Serum

Necessary Information

Date of collection is required.

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Centrifuge blood collection tube per collection tube manufacturer's instructions (eg, centrifuge and aliquot within 2 hours of collection for BD Vacutainer tubes).

2. Aliquot serum into plastic vial.

Useful For

Detection of previous exposure or immunity to hepatitis A infection

Special Instructions

Method Name

Chemiluminescent Microparticle Immunoassay (CMIA)

Reporting Name

Hepatitis A IgG Ab, S

Specimen Type


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 8 days
  Ambient  4 days

Clinical Information

Hepatitis A virus (HAV) is endemic throughout the world, occurring most commonly in areas of poor hygiene and low socioeconomic conditions. The virus is transmitted primarily by the fecal-oral route and spread by close person-to-person contact as well as by food and waterborne epidemics. Outbreaks frequently occur in overcrowded situations and high-density institutions and centers, such as prisons and healthcare or daycare centers. Viral spread by parenteral routes (eg, exposure to blood) is possible, but rare, because infected individuals are viremic for a short period of time (usually <3 weeks). There is little or no evidence of transplacental transmission from mother to fetus or transmission to newborn during delivery.


In most cases of acute viral hepatitis A, IgM antibodies to HAV (anti-HAV IgM) are detectable by the time symptoms occur, usually 15 to 45 days after exposure. HAV-specific IgM antibody level in serum usually falls to an undetectable level by 6 months after acute infection. HAV-specific IgG antibody (anti-HAV IgG) level in serum rises quickly once the virus is cleared and may persist for many years.

Reference Values

Unvaccinated: Negative

Vaccinated: Positive

See Viral Hepatitis Serologic Profiles.


This assay detects the presence of hepatitis A virus (HAV)-specific IgG antibody in serum. 


A negative result indicates the absence of HAV-specific IgG antibody, implying no past exposure or immunity to HAV infection.


A positive result indicates the presence of HAV-specific IgG antibody from either vaccination or past exposure to hepatitis A virus.

Clinical Reference

1. Nelson NP, Weng MK, Hofmeister MG, et al: Prevention of hepatitis A virus infection in the United States: Recommendations of the Advisory Committee on Immunization Practices, 2020. MMWR Morb Mortal Wkly Rep. 2020 Jul 3;69(5):1-38. Erratum in MMWR Morb Mortal Wkly Rep. 2021 Feb 26;70(8):294

2. de Paula VS: Laboratory diagnosis of hepatitis A. Future Virology. 2012;7(5):461-472

3. Webb GW, Kelly S, Dalton HR: Hepatitis A and hepatitis E: clinical and epidemiological features, diagnosis, treatment, and prevention. Clin Microbiol Newsl. 2020 Nov 1;42(21):171-179

Day(s) Performed

Monday through Saturday

Report Available

1 to 2 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
HAIGG Hepatitis A IgG Ab, S 40724-7


Result ID Test Result Name Result LOINC Value
HAIGG Hepatitis A IgG Ab, S 40724-7


If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-General Request (T239)

-Gastroenterology and Hepatology Client Test Request (T728)

-Infectious Disease Serology Test Request (T916)

Mayo Clinic Laboratories | Microbiology and Infectious Disease Catalog Additional Information: