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HelpTest ID: CMVGS Cytomegalovirus Antibody, IgG, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.6 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial
Useful For
Determining whether a patient has had previous exposure to or recent infection with cytomegalovirus, including pregnant women.
This test is not useful for screening blood or plasma donors, or neonatal screening.
Method Name
Electrochemiluminescence Immunoassay (ECLIA)
Reporting Name
CMV Ab, IgG, SSpecimen Type
SerumSpecimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 180 days | |
| Ambient | 7 days |
Clinical Information
Cytomegalovirus (CMV) is a member of the Herpesviridae family of viruses and usually causes asymptomatic infection after which it remains latent in patients, primarily within bone marrow-derived cells. Primary CMV infection in immunocompetent individuals may also manifest as a mononucleosis-type syndrome, similar to primary Epstein-Barr virus infection, with fever, malaise, and lymphadenopathy.
Cytomegalovirus is a significant cause of morbidity and mortality among bone marrow or solid organ transplant recipients, individuals with AIDS, and other immunosuppressed patients due to virus reactivation or a newly acquired infection. Infection in these patient populations can affect almost any organ and lead to multiorgan failure. CMV is also responsible for congenital disease among newborns and is one of the TORCH infections (toxoplasmosis, other infections including syphilis, rubella, CMV, and herpes simplex virus).
Cytomegalovirus seroprevalence increases with age. In the US, the prevalence of CMV specific antibodies increases from approximately 36% in children aged 6 to 11 years to over 91% in adults older than 80 years.(4)
Reference Values
Negative
Reference values apply to all ages.
Interpretation
Negative
Negative for cytomegalovirus (CMV) IgG. False negative results may occur in immunocompromised patients.
Borderline
Recommend follow-up testing in 10 to 14 days if clinically indicated.
Positive
Cytomegalovirus IgG antibodies detected, which indicate recent or remote infection.
Clinical Reference
1. Fowler K, Mucha J, Neumann M, et al. A systematic literature review of the global seroprevalence of cytomegalovirus: possible implications for treatment, screening, and vaccine development. BMC Public Health. 2022;22(1):1659
2. Limaye AP, Babu TM, Boeckh M. Progress and challenges in the prevention, diagnosis, and management of cytomegalovirus infection in transplantation. Clin Microbiol Rev. 2020;34(1):e00043-19
3. Leber AL. Maternal and congenital human cytomegalovirus infection: laboratory testing for detection and diagnosis. J Clin Microbiol. 2024;62(4):e0031323. doi:10.1128/jcm.00313-23
4. Bruminhent J, Thongprayoon C, Dierkhising RA, Kremers WK, Theel ES, Razonable RR. Risk factors for cytomegalovirus reactivation after liver transplantation: Can pre-transplant cytomegalovirus antibody titers predict outcome?. Liver Transpl. 2015;21(4):539-46. doi:10.1002/lt.2407
5.Dioverti MV, Razonable RR. Cytomegalovirus. Diagnostic Microbiology of the Immunocompromised Host. 2016 Aug 15:97-125
Day(s) Performed
Monday through Saturday
Report Available
Same day/1 to 3 daysTest Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86644
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CMVGS | CMV Ab, IgG, S | 22244-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| GCMV | CMV Ab, IgG, S | 22244-8 |
Forms
If not ordering electronically, complete, print, and send an Infectious Disease Serology Test Request (T916) with the specimen.