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Test ID: CMUMP Mumps Virus Antibodies, IgG and IgM, Spinal Fluid

Reporting Name

Mumps Virus Ab, IgG and IgM, CSF

Useful For

Aiding in the diagnosis of central nervous system infection by mumps virus

Specimen Type

CSF


Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

IgG: <1:5

IgM: <1:10

Reference values apply to all ages.

Day(s) Performed

Monday through Friday

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86735 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CMUMP Mumps Virus Ab, IgG and IgM, CSF 88458-5

 

Result ID Test Result Name Result LOINC Value
1414 Mumps Virus Ab, IgG 21401-5
1415 Mumps Virus Ab, IgM 21402-3

Clinical Information

There is only one serotype of mumps virus that infects humans. Mumps has been recognized since antiquity by virtue of the parotitis, which is often a striking clinical feature of the disease. Generally, a trivial childhood illness, the varied presentation of mumps reflects the widespread invasion of visceral organs and central nervous system that commonly follows infection with mumps virus.

Interpretation

Detection of organism-specific antibodies in the cerebrospinal fluid (CSF) may suggest central nervous system infection. However, these results are unable to distinguish between intrathecal antibodies and serum antibodies introduced into the CSF at the time of lumbar puncture or from a breakdown in the blood-brain barrier. The results should be interpreted with other laboratory and clinical data prior to a diagnosis of central nervous system infection.

Clinical Reference

1. Wolinsky J, Waxham MN: Mumps virus. In: Fields BN, Knipe DM eds. Fields Virology. Vol 1. 2nd ed. Raven Press; 1990:989-1011

2. Litman N, Baum SG: Mumps virus. In Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:2087-2092

Report Available

Same day/1 to 3 days

Method Name

Immunofluorescence

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.

Mayo Clinic Laboratories | Microbiology and Infectious Disease Catalog Additional Information:

mml-mbid-cnsinfections